Two sample MR report
KANSL1-AS1_T Proliferating against UKB-b-18436
Date: 13 January, 2026
Results from two sample MR:
| method | nsnp | b | se | pval |
|---|---|---|---|---|
| MR Egger | 56 | 0.0275473 | 0.0198735 | 0.1714033 |
| Weighted median | 56 | 0.0261174 | 0.0033913 | 0.0000000 |
| Inverse variance weighted | 56 | 0.0222123 | 0.0026000 | 0.0000000 |
| Simple mode | 56 | 0.0263712 | 0.0076894 | 0.0011531 |
| Weighted mode | 56 | 0.0262214 | 0.0072012 | 0.0006010 |
Heterogeneity tests
| method | Q | Q_df | Q_pval |
|---|---|---|---|
| MR Egger | 25.78513 | 54 | 0.9996005 |
| Inverse variance weighted | 25.85845 | 55 | 0.9997193 |
Test for directional horizontal pleiotropy
| egger_intercept | se | pval |
|---|---|---|
| -0.0039432 | 0.0145626 | 0.7875977 |
Test that the exposure is upstream of the outcome
| snp_r2.exposure | snp_r2.outcome | correct_causal_direction | steiger_pval |
|---|---|---|---|
| 0.0007615 | 0 | TRUE | 0.0088882 |
Note - R^2 values are approximate
Forest plot of single SNP MR
Comparison of results using different MR methods
Funnel plot
Leave-one-out sensitivity analysis
